Main Article: Runes
- Power-up Runes
- Power-up runes start spawning at the 6:00 minute mark, and then every 2 minutes (8:00, 10:00, 12:00, etc.)
- They spawn at one of the rune spots within the river, which is randomly chosen.
- If a Power Rune is not picked up before the next one spawns, it disappears.
- The same Power-up Rune cannot spawn twice in a row.
- Can fully regenerate a unit's health and mana within 16.67 seconds.
- The buff disappears once the hero is at full health and mana.
- Damage greater than
from any player (including allies and self) or dispels the effect.
- Does not get dispelled by damage flagged as HP Removal.
- The buff of multiple Regeneration Runes does not stack, but refreshes the duration instead.